4-(4-Fluorophenyl)-4-hydroxypiperidine hydrochloride is an organic compound with the chemical formula C12H15ClFN and a molecular weight of 235.71g/mol. It is a white crystalline solid, soluble in water and organic solvents.
This compound has some utility in the pharmaceutical field. It can be used as a pharmaceutical intermediate for the synthesis of a variety of bioactive compounds. Specifically, it can be used in the synthesis of antidepressants, analgesics, anesthetics, hemostatic agents, and the like. In addition, due to its heterocyclic structure, it can also be used as an efficient catalyst in organic synthesis reactions.
The preparation of 4-(4-Fluorophenyl)-4-hydroxypiperidine hydrochloride is usually achieved by a substitution reaction. First, piperidine is reacted with decarboxylating p-fluorobenzoic acid to give 4-(4-fluorophenyl)-4-hydroxypiperidine. This is then reacted with hydrochloric acid to give 4-(4-Fluorophenyl)-4-hydroxypiperidine hydrochloride.
For safety information, this compound should be considered a hazardous substance. During use and storage, the relevant safety procedures shall be observed. Avoid contact with skin, eyes and respiratory tract, and make sure to operate in a well-ventilated area. In case of contact, rinse immediately with plenty of water and seek medical attention.